Dr. Ehsan Amin

Formation & Diplômes

Expérience professionnelle

Publications

2025

• Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.
• Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.

2023

• Wagner, J.U.G., Tombor, L.S., Malacarne, P.F., Kettenhausen, L.M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K.A., et al. (2023). Aging impairs the neurovascular interface in the heart. Science, 381(6660), 897–906.
• Bazgir, F., Nau, J., Nakhaei-Rad, S., Amin, E., Wolf, M.J., Saucerman, J.J., Lorenz, K., & Ahmadian, M.R. (2023). The microenvironment of the pathogenesis of cardiac hypertrophy. Cells, 12(13), 1780.
• Moussavi-Torshizi, S.E., Amin, E., & Klöcker, N. (2023). Sex-specific repolarization heterogeneity in mouse left ventricle: Optical mapping combined with mathematical modeling predict the contribution of specific ionic currents. Physiological Reports, 11(11), e15670.
• Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., Gödecke, A., & Heinen, A. (2023). Extracellular flux analysis in intact cardiac tissue slices—A novel tool to investigate cardiac substrate metabolism in mouse myocardium. Acta Physiologica, 239(2), e14004.
• Angendohr, D.S., Dannenberg, D.L., Amin, D.E., Scherschel, D.K., Benkhoff, M., Baensch, L., Weber, J., Gerdes, N., Polzin, D.A., Rana, D.O., et al. (2023). Sustained high-fat diet increases ventricular susceptibility to arrhythmias and impairs myocardial calcium cycling. Europace, 25(Suppl 1), euad122-585.

2022

• Heinen, A., Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., & Gödecke, A. (2022). A New Method to Analyse Myocardial Substrate Metabolism and Mitochondrial Function in Intact Cardiac Tissue Slices. The FASEB Journal, 36.

2021

• Mosaddeghzadeh, N., Nouri, K., Krumbach, O.H.F., Amin, E., Dvorsky, R., & Ahmadian, M.R. (2021). Selectivity determinants of RHO GTPase binding to IQGAPs. International Journal of Molecular Sciences, 22(22), 12596.
• Scherschel, K., Bräuninger, H., Mölders, A., Erlenhardt, N., Amin, E., Jungen, C., Pape, U., Lindner, D., Chetkovich, D.M., Klöcker, N., et al. (2021). Characterization of the HCN interaction partner TRIP8b/PEX5R in the intracardiac nervous system of TRIP8b-deficient and wild-type mice. International Journal of Molecular Sciences, 22(9), 4772.
• Adariani, S.R., Jasemi, N.S.K., Bazgir, F., Wittich, C., Amin, E., Seidel, C.A.M., Dvorsky, R., & Ahmadian, M.R. (2021). A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners. Journal of Biological Chemistry, 296.

2019

• Amin, E., Saboury, A.A., Mansouri-Torshizi, H., & Zolghadri, S. (2019). Inhibition Properties and Thermodynamic Changes of Binding of p-perazine-bis and p-peridine Dithiocarbamate Sodium Salts to Mushroom Tyrosinase. Iranian Journal of Chemistry and Chemical Engineering, 38(3), 127–136.
• Martinelli, S., Krumbach, O., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2019). Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. In European Journal of Human Genetics, 27, 833–833.

2018

• Martinelli, S., Krumbach, O.H.F., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2018). Functional dysregulation of CDC42 causes diverse developmental phenotypes. The American Journal of Human Genetics, 102(2), 309–320.
• Amin, E., & Ahmadian, M.R. (2018). Regulators of Rho signaling. In Rho GTPases: Molecular Biology in Health and Disease (pp. 33–51).

2016

• Amin, E., Jaiswal, M., Derewenda, U., Reis, K., Nouri, K., Koessmeier, K.T., Aspenström, P., Somlyo, A.V., Dvorsky, R., & Ahmadian, M.R. (2016). Deciphering the molecular and functional basis of RHOGAP family proteins: a systematic approach toward selective inactivation of RHO family proteins. Journal of Biological Chemistry, 291(39), 20353–20371.
• Becker, M.S., Müller, P.M., Bajorat, J., Schroeder, A., Giaisi, M., Amin, E., Ahmadian, M.R., Rocks, O., Köhler, R., Krammer, P.H., et al. (2016). The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration. Oncotarget, 7(32), 51908.
• Nouri, K., Fansa, E.K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D.J., & Ahmadian, M.R. (2016). IQGAP1 interaction with RHO family proteins revisited: kinetic and equilibrium evidence for multiple distinct binding sites. Journal of Biological Chemistry, 291(51), 26364–26376.
• Nakhaeizadeh, H., Amin, E., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2016). The RAS-effector interface: Isoform-specific differences in the effector binding regions. PloS ONE, 11(12), e0167145.

2015

• Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S.-C., Ahmadian, M.R., Brakebusch, C., & Nieswandt, B. (2015). Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. Journal of Thrombosis and Haemostasis, 13(5), 827–838.
• Nouri, K., Moll, J.M., Milroy, L.-G., Hain, A., Dvorsky, R., Amin, E., Lenders, M., Nagel-Steger, L., Howe, S., Smits, S.H.J., et al. (2015). Biophysical characterization of nucleophosmin interactions with HIV Rev and HSV US11. PloS ONE, 10(12), e0143634.
• Nakhaeizadeh, H., Nakhaei-Rad, S., Amin, E., Kordes, C., Häussinger, D., & Ahmadian, M.R. (2015). The impact of the interaction between Embryonic stem cell-expressed Ras and Arginase-1 in hepatic stellate cells. Zeitschrift für Gastroenterologie, 53(12), A3_30.

2014

• Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.-C., Taha, M.S., Gauhar, A.R., Nakhaei-Rad, S., Kordes, C., et al. (2014). Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, 289(10), 6839–6849.
• Zhang, S.-C., Nouri, K., Amin, E., Taha, M.S., Nakhaeizadeh, H., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2014). Classical Rho Proteins: Biochemistry of Molecular Switch Function and Regulation. In Ras Superfamily Small G Proteins (pp. 327–340). Springer Vienna.
• Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.C., & Taha, M.S. (2014). Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger. In vitro Liposomen-Rekonstitution intrazellulärer Signaltransduktion kleiner GTPasen, 34.

2013

• Amin, E., Dubey, B.N., Zhang, S.-C., Gremer, L., Dvorsky, R., Moll, J.M., Taha, M.S., Nagel-Steger, L., Piekorz, R.P., Somlyo, A.V., et al. (2013). Rho-kinase: regulation, (dys)function, and inhibition. Biological Chemistry, 394(11), 1399–1410.

2010

• Amin, E., Saboury, A.A., Mansuri-Torshizi, H., & Moosavi-Movahedi, A.A. (2010). Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase. Journal of Enzyme Inhibition and Medicinal Chemistry, 25(2), 272–281.
• Amin, E., Saboury, A.A., Mansouri-Torshizi, H., Zolghadri, S., & Bordbar, A.K. (2010). Evaluation of p-phenylene-bis and phenyl dithiocarbamate sodium salts as inhibitors of mushroom tyrosinase. Acta Biochimica Polonica, 57(3), 277–283.
• Zolghadri, S., Saboury, A.A., Amin, E., & Moosavi-Movahedi, A.A. (2010). A spectroscopic study on the interaction between ferric oxide nanoparticles and human hemoglobin. Journal of the Iranian Chemical Society, 7, S145–S153.