Dr. Ehsan Amin

Dr. Ehsan Amin

Professeur expert
Domaine(s) d'expertise
Biotechnology, Artificial intelligence, Data Science

Ehsan Amin est un Data Scientist et un Life Scientist chevronné, doté d'une expertise approfondie en biotechnologie, en analyse de données cliniques et en intelligence artificielle. Il allie de solides compétences analytiques à une formation scientifique en biochimie et en bioinformatique. Ehsan a dirigé des projets de recherche multidisciplinaires et développé des outils avancés de traitement des données, y compris des applications d'apprentissage automatique et des technologies de préservation de la vie privée. Fort d'une expérience dans l'enseignement et l'industrie à travers l'Europe, il est également activement impliqué dans la conformité des données médicales, le prototypage d'IA et la collaboration scientifique.

AnnéeUniversitéDiplôme/Poste
2012 - 2016Heinrich Heine University, DüsseldorfPh.D. in Biophysics

Expérience professionnelle

AnnéeFonction
2024– presentData Scientist / Anonymization Expert – xValue GmbH, Ratingen, Germany
2017–2024Senior Scientist – University Hospital Düsseldorf

2025

  • Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.
  • Fehrentz, T., Amin, E., Görldt, N., Strasdeit, T., Moussavi-Torshizi, S.E., Leippe, P., Trauner, D., Meyer, C., Frey, N., & Sasse, P., et al. (2025). Optical control of cardiac electrophysiology by the photochromic ligand azobupivacaine 2. British Journal of Pharmacology.

2023

  • Wagner, J.U.G., Tombor, L.S., Malacarne, P.F., Kettenhausen, L.M., Panthel, J., Kujundzic, H., Manickam, N., Schmitz, K., Cipca, M., Stilz, K.A., et al. (2023). Aging impairs the neurovascular interface in the heart. Science, 381(6660), 897–906.
  • Bazgir, F., Nau, J., Nakhaei-Rad, S., Amin, E., Wolf, M.J., Saucerman, J.J., Lorenz, K., & Ahmadian, M.R. (2023). The microenvironment of the pathogenesis of cardiac hypertrophy. Cells, 12(13), 1780.
  • Moussavi-Torshizi, S.E., Amin, E., & Klöcker, N. (2023). Sex-specific repolarization heterogeneity in mouse left ventricle: Optical mapping combined with mathematical modeling predict the contribution of specific ionic currents. Physiological Reports, 11(11), e15670.
  • Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., Gödecke, A., & Heinen, A. (2023). Extracellular flux analysis in intact cardiac tissue slices—A novel tool to investigate cardiac substrate metabolism in mouse myocardium. Acta Physiologica, 239(2), e14004.
  • Angendohr, D.S., Dannenberg, D.L., Amin, D.E., Scherschel, D.K., Benkhoff, M., Baensch, L., Weber, J., Gerdes, N., Polzin, D.A., Rana, D.O., et al. (2023). Sustained high-fat diet increases ventricular susceptibility to arrhythmias and impairs myocardial calcium cycling. Europace, 25(Suppl 1), euad122-585.

2022

  • Heinen, A., Bottermann, K., Spychala, A., Eliacik, A., Amin, E., Moussavi-Torshizi, S.E., Klöcker, N., & Gödecke, A. (2022). A New Method to Analyse Myocardial Substrate Metabolism and Mitochondrial Function in Intact Cardiac Tissue Slices. The FASEB Journal, 36.

2021

  • Mosaddeghzadeh, N., Nouri, K., Krumbach, O.H.F., Amin, E., Dvorsky, R., & Ahmadian, M.R. (2021). Selectivity determinants of RHO GTPase binding to IQGAPs. International Journal of Molecular Sciences, 22(22), 12596.
  • Scherschel, K., Bräuninger, H., Mölders, A., Erlenhardt, N., Amin, E., Jungen, C., Pape, U., Lindner, D., Chetkovich, D.M., Klöcker, N., et al. (2021). Characterization of the HCN interaction partner TRIP8b/PEX5R in the intracardiac nervous system of TRIP8b-deficient and wild-type mice. International Journal of Molecular Sciences, 22(9), 4772.
  • Adariani, S.R., Jasemi, N.S.K., Bazgir, F., Wittich, C., Amin, E., Seidel, C.A.M., Dvorsky, R., & Ahmadian, M.R. (2021). A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners. Journal of Biological Chemistry, 296.

2019

  • Amin, E., Saboury, A.A., Mansouri-Torshizi, H., & Zolghadri, S. (2019). Inhibition Properties and Thermodynamic Changes of Binding of p-perazine-bis and p-peridine Dithiocarbamate Sodium Salts to Mushroom Tyrosinase. Iranian Journal of Chemistry and Chemical Engineering, 38(3), 127–136.
  • Martinelli, S., Krumbach, O., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2019). Functional Dysregulation of CDC42 Causes Diverse Developmental Phenotypes. In European Journal of Human Genetics, 27, 833–833.

2018

  • Martinelli, S., Krumbach, O.H.F., Pantaleoni, F., Coppola, S., Amin, E., Pannone, L., Nouri, K., Farina, L., Dvorsky, R., Lepri, F., et al. (2018). Functional dysregulation of CDC42 causes diverse developmental phenotypes. The American Journal of Human Genetics, 102(2), 309–320.
  • Amin, E., & Ahmadian, M.R. (2018). Regulators of Rho signaling. In Rho GTPases: Molecular Biology in Health and Disease (pp. 33–51).

2016

  • Amin, E., Jaiswal, M., Derewenda, U., Reis, K., Nouri, K., Koessmeier, K.T., Aspenström, P., Somlyo, A.V., Dvorsky, R., & Ahmadian, M.R. (2016). Deciphering the molecular and functional basis of RHOGAP family proteins: a systematic approach toward selective inactivation of RHO family proteins. Journal of Biological Chemistry, 291(39), 20353–20371.
  • Becker, M.S., Müller, P.M., Bajorat, J., Schroeder, A., Giaisi, M., Amin, E., Ahmadian, M.R., Rocks, O., Köhler, R., Krammer, P.H., et al. (2016). The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration. Oncotarget, 7(32), 51908.
  • Nouri, K., Fansa, E.K., Amin, E., Dvorsky, R., Gremer, L., Willbold, D., Schmitt, L., Timson, D.J., & Ahmadian, M.R. (2016). IQGAP1 interaction with RHO family proteins revisited: kinetic and equilibrium evidence for multiple distinct binding sites. Journal of Biological Chemistry, 291(51), 26364–26376.
  • Nakhaeizadeh, H., Amin, E., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2016). The RAS-effector interface: Isoform-specific differences in the effector binding regions. PloS ONE, 11(12), e0167145.

2015

  • Dütting, S., Heidenreich, J., Cherpokova, D., Amin, E., Zhang, S.-C., Ahmadian, M.R., Brakebusch, C., & Nieswandt, B. (2015). Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. Journal of Thrombosis and Haemostasis, 13(5), 827–838.
  • Nouri, K., Moll, J.M., Milroy, L.-G., Hain, A., Dvorsky, R., Amin, E., Lenders, M., Nagel-Steger, L., Howe, S., Smits, S.H.J., et al. (2015). Biophysical characterization of nucleophosmin interactions with HIV Rev and HSV US11. PloS ONE, 10(12), e0143634.
  • Nakhaeizadeh, H., Nakhaei-Rad, S., Amin, E., Kordes, C., Häussinger, D., & Ahmadian, M.R. (2015). The impact of the interaction between Embryonic stem cell-expressed Ras and Arginase-1 in hepatic stellate cells. Zeitschrift für Gastroenterologie, 53(12), A3_30.

2014

  • Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.-C., Taha, M.S., Gauhar, A.R., Nakhaei-Rad, S., Kordes, C., et al. (2014). Functional cross-talk between ras and rho pathways: a Ras-specific GTPase-activating protein (p120RasGAP) competitively inhibits the RhoGAP activity of deleted in liver cancer (DLC) tumor suppressor by masking the catalytic arginine finger. Journal of Biological Chemistry, 289(10), 6839–6849.
  • Zhang, S.-C., Nouri, K., Amin, E., Taha, M.S., Nakhaeizadeh, H., Nakhaei-Rad, S., Dvorsky, R., & Ahmadian, M.R. (2014). Classical Rho Proteins: Biochemistry of Molecular Switch Function and Regulation. In Ras Superfamily Small G Proteins (pp. 327–340). Springer Vienna.
  • Jaiswal, M., Dvorsky, R., Amin, E., Risse, S.L., Fansa, E.K., Zhang, S.C., & Taha, M.S. (2014). Functional crosstalk between Ras and Rho pathways: p120RasGAP competitively inhibits the RhoGAP activity of Deleted in Liver Cancer (DLC) tumor suppressors by masking its catalytic arginine finger. In vitro Liposomen-Rekonstitution intrazellulärer Signaltransduktion kleiner GTPasen, 34.

2013

  • Amin, E., Dubey, B.N., Zhang, S.-C., Gremer, L., Dvorsky, R., Moll, J.M., Taha, M.S., Nagel-Steger, L., Piekorz, R.P., Somlyo, A.V., et al. (2013). Rho-kinase: regulation, (dys)function, and inhibition. Biological Chemistry, 394(11), 1399–1410.

2010

  • Amin, E., Saboury, A.A., Mansuri-Torshizi, H., & Moosavi-Movahedi, A.A. (2010). Potent inhibitory effects of benzyl and p-xylidine-bis dithiocarbamate sodium salts on activities of mushroom tyrosinase. Journal of Enzyme Inhibition and Medicinal Chemistry, 25(2), 272–281.
  • Amin, E., Saboury, A.A., Mansouri-Torshizi, H., Zolghadri, S., & Bordbar, A.K. (2010). Evaluation of p-phenylene-bis and phenyl dithiocarbamate sodium salts as inhibitors of mushroom tyrosinase. Acta Biochimica Polonica, 57(3), 277–283.
  • Zolghadri, S., Saboury, A.A., Amin, E., & Moosavi-Movahedi, A.A. (2010). A spectroscopic study on the interaction between ferric oxide nanoparticles and human hemoglobin. Journal of the Iranian Chemical Society, 7, S145–S153.